The mission of the SIGN is to foster therapies of brain and spinal cord disorders
 while preventing toxicity to the rest of the body through advancing methods for
image-guided neurointerventions.

ABOUT SIGN

SIGN is a non-profit entity composed of scientists, engineers and clinicians. The initiative to launch SIGN came from the unique opportunity provided by growing technological capacity within several different fields including interventional neuroradiology, MRI, PET, neuropharmacology and artificial intelligence. In 2018 when the society has been established each of these fields offered tools of unprecedented utility such as potent therapeutic agents, methods for selective drug delivery, visualizing brain structure and function, as well as enormous calculation power. Importantly, these converging fields offer great synergy and added value when combined. The SIGN is a non-profit organization supported by its members and by donations.

MEET OUR PEOPLE

Dr. Miroslaw Janowski

PRESIDENT

Dr. Monica Pearl

SECRETARY

Dr. Piotr Walczak

TREASURER

Dr. Michał Zawadzki

VICE-PRESIDENT

Dr. Miroslaw Janowski

Dr. Miroslaw Janowski is a neurosurgeon by training and currently serves as Associate Professor at the Department of Radiology at Johns Hopkins University. The long-term interests of Dr. Janowski include minimally invasive methods of delivery of therapeutic agents, including stem cells, to the central nervous system, with a special emphasis on intra-arterial route. He pioneered utilization of molecular imaging including CEST MRI to the field of intra-arterial targeting, and currently is pursuing frontiers of other imaging modalities to further improve the precision and predictability of intra-arterial neurointerventions.

Dr. Monica Pearl

Dr. Monica Pearl is an Associate Professor in The Russell H. Morgan Department of Radiology and Radiological Science, Division of Interventional Neuroradiology at The Johns Hopkins University School of Medicine and the Director of Pediatric Neurointervention at Children’s National Medical Center. She is a clinically active Neurointerventionalist whose research focuses on intra-arterial drug delivery for CNS tumors and has expertise as the PI for two clinical trials on intra-arterial chemotherapy. Her recent contribution to this field is the creation of an imaging platform that utilizes both fluoroscopic based angiography and ultra-fast MRI for targeted blood brain barrier disruption and drug delivery in animal models.

Dr. Piotr Walczak

Dr. Piotr Walczak is the Associate Professor in The Russell H. Morgan Department

of Radiology and Radiological Science, Division of MR Research and The Institute for Cell Engineering Johns Hopkins University School of Medicine.  His research focuses on application on non-invasive imaging techniques for developing therapies for neurological disorders. His recent contribution to this field is application of ultra-fast MRI for guiding and visualization of the blood brain barrier opening procedure. This approach is utilized by Dr. Walczak’s group for improving precision and efficacy of delivering therapeutic agents to the brain parenchyma in animal brain tumor models.

Dr. Michał Zawadzki

Dr. Michał Zawadzki works as Coordinator of the Division of Interventional Radiology and Neuroradiology in the Department of Radiology of the Central Clinical Hospital of Ministry of the Interior and Administration in Warsaw. He is a clinically active Neurointerventionalist whose research focused on FD stents in the setting of subarachnoid hemorrhage and use of braided stents for complex aneurysms treatment. Recently, together with Dr. Janowski and Dr. Walczak after performing several animal experiments he performed first-in-human procedures of intra-arterial drug delivery to glioblastoma under real-time MRI guidance. His interests have now moved towards improvement of endovascular techniques of intra-arterial drug delivery to the brain, especially under real-time MRI guidance.

OUR FUTURE EVENTS

2ND SIGN MEETING | MAY/JUNE 2019 |  Baltimore  |  USA

OUR PAST EVENTS

1ST SIGN MEETING | 25-26 JUNE 2018 |  WARSAW  |  POLAND

LEGAL